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However, the use of anabolic steroids in the absence or interference of medical advice or steroid use for functions besides medical is what comprises steroid abusein many cases. Steroid abuse can lead to irreversible damage, even when steroid use is taken by athletes without the presence of medical conditions. Those taking steroids under the influence of a physician or medical professional do not require any special consideration. However, we now need to take that into consideration when evaluating the potential harm caused by anti-depression medication. Steroidal Hormones in the Brain Steroid use causes hormonal changes within the brain. This is because steroid use is a "by-product of the body changing to respond to external stimuli" (Widom et al 1999, p. 773). During or after steroid use, neurotransmitters within the brain change. For example, the neurotransmitter GABA plays a critical role in maintaining balance in the body, affecting the functions of the brain, including mood, consciousness, mood behavior and sleep. Steroid abuse disrupts the function of GABA in several ways. Steroid use causes changes in the GABA receptor subtype within neurons. The effects of steroid use on GABA may be reversible, but are irreversible in some areas. If there are chronic effects caused by steroid use on GABA levels, these levels do not recover and the negative effects of steroid use persist. This causes permanent and irreversible changes to the functioning of GABA receptors. GABA function will not be restored when the effects of steroid use are removed. At this point, the levels of GABA within neurons have not been normalized and no recovery has been recorded after steroid use is discontinued. Furthermore, long-term steroid abuse is associated with decreases in the expression of GABA in the brain (Zhang and Zhang 1995, Zhang et al 2002). Steroid abusers are also unable to restore GABA levels to normal levels after discontinuing the use of anabolic steroids (Zhang et al 2002). The effects of steroid use on GABA function can also be modified by the use of other anti-depressant medications. In studies of a population with chronic steroid abuse, researchers report decreased GABA levels in regions of the brain responsible for the control of mood during the use of antidepressant medications (Hoyland et al 1999, Hu et al 2003, Zolke et al 2003). In patients who take SSRIs to treat depression, the use of these medications can decrease the GABA effect in regions of the brain responsible for serotonin, such as the amygdala. Researchers also note that this decrease in the GABA level can be accompanied by an increase in a number of neurotransmitters. Steroid Related Article: